CALL FOR PAPERS Mitochondria in Cardiovascular Physiology and Disease Nox-derived ROS are acutely activated in pressure overload pulmonary hypertension: indications for a seminal role for mitochondrial Nox4
نویسندگان
چکیده
Giovanna Frazziano,* Imad Al Ghouleh,* Jeff Baust, Sruti Shiva, Hunter C. Champion, and Patrick J. Pagano Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania; Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania; and Fondazione Ri.MED, Palermo, Italy
منابع مشابه
NADPH oxidase-derived ROS and the regulation of pulmonary vessel tone.
Pulmonary vessel constriction results from an imbalance between vasodilator and vasoconstrictor factors released by the endothelium including nitric oxide, endothelin, prostanoids, and reactive oxygen species (ROS). ROS, generated by a variety of enzymatic sources (such as mitochondria and NADPH oxidases, a.k.a. Nox), appear to play a pivotal role in vascular homeostasis, whereas elevated level...
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Nazarewicz RR, Dikalova AE, Bikineyeva A, Dikalov SI. Nox2 as a potential target of mitochondrial superoxide and its role in endothelial oxidative stress. Am J Physiol Heart Circ Physiol 305: H1131–H1140, 2013. First published August 16, 2013; doi:10.1152/ajpheart.00063.2013.—Superoxide (O2 ) production by the NADPH oxidases is implicated in the pathogenesis of many cardiovascular diseases, inc...
متن کاملHypertension Highlights Reactive Oxygen Species, NADPH Oxidases, and Hypertension
Reactive oxygen species (ROS) produced in the neuronal, renal, and vascular systems not only influence cardiovascular physiology but are also strongly implicated in pathological signaling leading to hypertension. Different sources of ROS have been identified, ranging from xanthinexanthine oxidase and mitochondria to NADPH oxidase (Nox) enzymes. Of 7 Nox family members, Nox1, Nox2, and Nox4 (and...
متن کاملReactive oxygen species, NADPH oxidases, and hypertension.
Reactive oxygen species (ROS) produced in the neuronal, renal, and vascular systems not only influence cardiovascular physiology but are also strongly implicated in pathological signaling leading to hypertension. Different sources of ROS have been identified, ranging from xanthinexanthine oxidase and mitochondria to NADPH oxidase (Nox) enzymes. Of 7 Nox family members, Nox1, Nox2, and Nox4 (and...
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Dikalov SI, Ungvari Z. Role of mitochondrial oxidative stress in hypertension. Am J Physiol Heart Circ Physiol 305: H1417–H1427, 2013. First published September 11, 2013; doi:10.1152/ajpheart.00089.2013.—Based on mosaic theory, hypertension is a multifactorial disorder that develops because of genetic, environmental, anatomical, adaptive neural, endocrine, humoral, and hemodynamic factors. It h...
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